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Laboratory 17

Science · Research overview

Biological effects of cyanobacteria and microalgae

What is known from the literature, which studies are under way in humans, and what has been studied on cells and laboratory animals in the work of Alexander P. Lykov and co-authors.

What these organisms are and why they are of interest

Cyanobacteria are photosynthetic microorganisms without a nucleus (prokaryotes). They capture the energy of sunlight and use it to make primary metabolites — the proteins, fats and carbohydrates cells need to live and divide — and secondary metabolites. Secondary metabolites are biologically active compounds that are not essential for survival but help the organism, for example, to compete for its habitat and to defend itself against infections [1].

The ability of cyanobacteria to produce substances with antimicrobial potential, including antimicrobial peptides, is being studied as a possible source of new antibiotics against multidrug-resistant microorganisms [2]. Cyanobacteria and microalgae are also considered as a raw material for food, feed additives, chemicals, biofuels and pharmaceutical substances: carotene, astaxanthin, polyunsaturated fatty acids — docosahexaenoic (DHA) and eicosapentaenoic (EPA) — and polysaccharides such as glucans [3].

Microalgae — single-celled algae with a nucleus — are also of interest for "green" technologies. Different species grown under different conditions yield biopolymers: polyhydroxybutyrate, polyurethane, polylactic acid, and polymers based on cellulose, starch and protein. According to the authors of the review, such bioplastics biodegrade, are compatible with living tissue, can be recycled and may be used in agriculture, construction, healthcare, electronics and packaging [4].

Microalgae produce β-glucans, omega-3 fatty acids and antioxidants. Recent reviews consider them a source of ingredients for functional foods, drug delivery systems and synthetic biology [5].

Studies in humans

Examples of clinical studies with microalgae from the ClinicalTrials.gov registry. Registration means a study was planned or carried out, not that an effect has been proven: results are published separately, and some studies are not yet complete.

  • NCT07791420 (opens in a new tab)

    Changes in blood and urine metabolites after drinks with milled and unmilled microalgae, compared with whey and soy protein and maltodextrin (placebo).

    Singapore, National University of Singapore · registered in 2026, recruitment not yet started

  • NCT05401591 (opens in a new tab)

    Microalgae as an alternative protein source in human nutrition: blood amino acids after intake.

    United Kingdom, University of Exeter · 2021–2022, completed

  • NCT05120791 (opens in a new tab)

    The microalga Phaeodactylum tricornutum in the diet of people of different ages: uptake of omega-3 fatty acids and blood parameters.

    Germany, University of Hohenheim · 2022, status not updated

  • NCT04851899 (opens in a new tab)

    A microalgae extract combined with a natural stimulant: cognitive function and gaming performance in video game players.

    USA, sponsor: Microphyt (France) · 2021–2022, completed

  • NCT04761406 (opens in a new tab)

    The same microalgae extract combined with exercise in healthy overweight women: weight management.

    USA, sponsor: Microphyt (France) · 2021–2023, completed

  • NCT01742468 (opens in a new tab)

    Long-chain omega-3 fatty acids from microalgae oil in patients with rheumatoid arthritis.

    Germany, University of Jena · 2013, completed

  • NCT03625284 (opens in a new tab)

    A fucoxanthin-rich supplement in non-alcoholic fatty liver disease.

    Sponsor: Algatechnologies (Israel) · 2018–2019, status not updated

  • NCT07173062 (opens in a new tab)

    Spirulina and the red seaweed Gelidium corneum: cardiovascular risk markers and gut microbiota.

    Portugal, University of Porto · started in 2025, recruiting

What reviews and experiments show

Work by other research groups on the possible health relevance of microalgae and cyanobacteria. For each, we state what the data were obtained on: results in mice cannot be transferred to humans.

  • mice

    Wound healing in diabetes

    A hydrogel with the live microalga Haematococcus, whose activity was switched by light, sped up the healing of infected wounds in diabetic mice. [6]

  • review

    Metabolic syndrome

    A review of cell and animal studies on the effects of microalgae on obesity, glucose and lipid metabolism, blood pressure and inflammation. [7]

  • meta-analysis: humans and animals

    Blood sugar

    In 7 clinical studies, spirulina (Arthrospira) supplements lowered fasting glucose and total cholesterol; glycated hemoglobin did not change significantly. Separately, 27 studies in rats and mice were analyzed. [8]

  • review

    Heart and blood vessels

    A review of compounds from marine microalgae — polysaccharides, peptides, carotenoids — with activity against age-related cardiovascular diseases in cell and animal experiments. [9]

  • reviews

    Anti-inflammatory, antimicrobial and antioxidant properties

    Reviews of substances from algae and cyanobacteria with such activity, including polymers with antiviral activity. [10, 11]

  • meta-analysis: humans

    Blood pressure

    29 randomized trials, 1,583 participants: eating edible algae, including seaweeds and spirulina, was associated with an average 2 mmHg reduction in blood pressure; the effect was larger with whole algae at more than 3 g a day for at least 12 weeks. [12]

  • mice

    Inflammatory bowel disease

    An oral hydrogel with spirulina and rhein alleviated chronic colitis and the associated anxiety- and depression-like behavior in mice. [13]

Studies led by Alexander P. Lykov

The biological effects of cyanobacteria and microalgae of different groups have been studied in cell cultures and laboratory mice. Below are the research directions and the related works in the publication library; each has an explanation in plain words.

  1. 01

    Effects of oil extracts on hematopoiesis

  2. 02

    Effects of oil extracts on blood biochemistry: glucose, proteins, lipids, cytokines, immunoglobulins, hormones

  3. 03

    Effects of oil extracts on immune cell function: proliferation and secretion

  4. 04

    A fucoxanthin carrier and fucoxanthin extracts: effects on cells and mice

  5. 05

    Antimicrobial properties of cyanobacteria and microalgae extracts

  6. 06

    Long-term non-specific immunological memory ("trained immunity")

  7. 07

    Human and rat mesenchymal stem cells and other somatic cells

  8. 08

    The marine cyanobacterium Leptolyngbya cf. ectocarpi: immune, liver and intestinal cells, metabolism

  9. 09

    Leptolyngbya cf. ectocarpi in mouse models of toxic hepatitis (ethanol, paracetamol) and intestinal inflammation

References

  1. [1]Melis A, Hidalgo Martinez DA, Betterle N. Perspectives of cyanobacterial cell factories. Photosynth Res. 2024;162(2–3):459–471. doi:10.1007/s11120-023-01056-4 (opens in a new tab)
  2. [2]Selvaraj C, Desai D, Santos-Villalobos SL, Jayaprakashvel M, Muthezhilan R, Singh SK. Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy. Adv Protein Chem Struct Biol. 2026;149:171–201. doi:10.1016/bs.apcsb.2025.08.002 (opens in a new tab)
  3. [3]Ibrahim TNBT, Feisal NAS, Kamaludin NH, Cheah WY, How V, Bhatnagar A, Ma Z, Show PL. Biological active metabolites from microalgae for healthcare and pharmaceutical industries: A comprehensive review. Bioresour Technol. 2023;372:128661. doi:10.1016/j.biortech.2023.128661 (opens in a new tab)
  4. [4]Adetunji AI, Erasmus M. Green Synthesis of Bioplastics from Microalgae: A State-of-the-Art Review. Polymers (Basel). 2024;16(10):1322. doi:10.3390/polym16101322 (opens in a new tab)
  5. [5]Li C, Du M, Han Y, Sun W, Chen Z, Liu Q, Zhu H, Zhao L, Li S, Wang J. Microalgae in health care and functional foods: β-glucan applications, innovations in drug delivery and synthetic biology. Front Pharmacol. 2025;16:1557298. doi:10.3389/fphar.2025.1557298 (opens in a new tab)
  6. [6]Kang Y, Xu L, Dong J, Yuan X, Ye J, Fan Y, Liu B, Xie J, Ji X. Programmed microalgae-gel promotes chronic wound healing in diabetes. Nat Commun. 2024;15(1):1042. doi:10.1038/s41467-024-45101-9 (opens in a new tab)
  7. [7]Tamel Selvan K, Goon JA, Makpol S, Tan JK. Effects of Microalgae on Metabolic Syndrome. Antioxidants (Basel). 2023;12(2):449. doi:10.3390/antiox12020449 (opens in a new tab)
  8. [8]Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis. Curr Probl Cardiol. 2022;47(10):100942. doi:10.1016/j.cpcardiol.2021.100942 (opens in a new tab)
  9. [9]Yurika N, Montuori E, Lauritano C. Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases. Mar Drugs. 2024;22(5):229. doi:10.3390/md22050229 (opens in a new tab)
  10. [10]Matin M, Koszarska M, Atanasov AG, Król-Szmajda K, Jóźwik A, Stelmasiak A, Hejna M. Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects. Molecules. 2024;29(19):4695. doi:10.3390/molecules29194695 (opens in a new tab)
  11. [11]da Silva MBF, Teixeira CMLL. Cyanobacterial and microalgae polymers: antiviral activity and applications. Braz J Microbiol. 2024;55(4):3287–3301. doi:10.1007/s42770-024-01452-5 (opens in a new tab)
  12. [12]Casas-Agustench P, Mínguez S, Brookes Z, Bescos R. Edible Algae Reduce Blood Pressure in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. J Hum Nutr Diet. 2025;38(4):e70095. doi:10.1111/jhn.70095 (opens in a new tab)
  13. [13]Zhong D, Jin K, Wang R, Chen B, Zhang J, Ren C, Chen X, Lu J, Zhou M. Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression. Adv Mater. 2024;36(24):e2312275. doi:10.1002/adma.202312275 (opens in a new tab)